One of the original members of Provincetown's famous Long Point Gallery (1977 to 1998), Hopkins was, in the words of the late poet and art critic John Perreault, "embedded in his time but also removed from it. His intelligence, which is clearly revealed in his writings about art, also shines through his paintings. He was an original."
Hopkins was part of a New York circle that included Mark Rothko, Robert Motherwell and Franz Kline. Trained at Oberlin, his hard-edged paintings, collages and architectonic sculptures inspired Michael Brenson to comment in The New York Times, "If the work is about sacrifice and violence, it is also about ecstasy and illumination. In the course of trying to re-establish the broadest meaning of abstract geometry that has fascinated so many 20th century artists, Hopkins makes us consider that ritual, worship, cruelty and superstition have always been inseparable."
Recipient of a 1976 National Endowment for the Arts Fellowship for Painting and a 1979 John Simon Guggenheim Fellowship for Painting, the artist is widely collected and is in the permanent collections of the Whitney Museum of Art, San Francisco Museum of Art and Guggenheim Museum. Hopkins had a profound connection to Wellfleet and was married to Franz Kline scholar and museum curator April Kingsley. They have a daughter, Grace, who is a well known art photographer.
A traveling museum exhibition was launched at the Provincetown Art Association and Museum in 2017.